Name: Baymont Inn and Suites by Wyndham Farmington, MO
Price range: $66 total
Rating: 8

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Grand Center

$396

per person

Apr 12 - Apr 15

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,022 reviews)

Great customer service. The locals there are friendly as well as the staff members

Reviewed on Feb 23, 2026

The Wildwood Hotel

$404

per person

Apr 10 - Apr 12

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,600 reviews)

Everything was great

Reviewed on Feb 23, 2026

Landing Apartments - Eureka

$655

per person

Apr 12 - Apr 15

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

No reviews

Hilton Pennywell St. Louis at the Arch

Downtown St. Louis

$605

per person

Apr 30 - May 4

found 2 hours ago

Roundtrip flight included

Los Angeles (LAX) to St. Louis (STL)

8.8/10 Excellent! (996 reviews)

Yea but truly my wife was the star of theshow

Reviewed on Feb 23, 2026

Ameristar Casino Resort and Spa

$482

per person

Apr 12 - Apr 15

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.4/10 Very Good! (1,006 reviews)

Unfortunately stay was just alittle disappointing then the stay before this one. Casino not giving free coffee to room as time before and had no vending machines whatsoever. Only had one lonely ice machine. Could not get chips or soda. Guessing it’s the time we live in. Just so sad

Reviewed on Feb 24, 2026

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Discover the most popular places to visit in Southeast Missouri

An old granite quarry that has filled with water. An beautiful spring hike around the lake got me this picture

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Southeast Missouri State University

4.5/5(76 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Lake Wappapello

4/5(18 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

100% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Mar 2 - Mar 3

Total with taxes and fees

9.6/10 Exceptional! (1,002 reviews)

Very helpful staff. Excellent facility

Reviewed on Feb 25, 2026

The Riverview

777 Main St Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$93 nightly

$105 total

Mar 10 - Mar 11

Total with taxes and fees

9.4/10 Exceptional! (512 reviews)

Beautiful facility

Reviewed on Feb 25, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$58 nightly

$66 total

Mar 8 - Mar 9

Total with taxes and fees

8/10 Very Good! (1,000 reviews)

Great staff and nice accommodations

Reviewed on Feb 16, 2026

See all 627 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.