Southeast Missouri Vacations from $418
Book a Hotel + Flight or Car together to unlock savings
Photo by JG Morris
Your Southeast Missouri Vacation
Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.
The Latest Southeast Missouri vacation packages
Price found within the past 48 hours. Click for updated prices.
The West End
Central West End
Price was $503, price is now $418 per person
$418
per person
Dec 18 - Dec 21
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
16.8/10 Exceptional! (389 reviews)
Everything was great. The host and staff were extremely friendly and helpful. Room was amazing and the perfect size for a nice relaxing weekend. We will return. Highly recommend.
Reviewed on Nov 17, 2025
The Wildwood Hotel
Price was $771, price is now $592 per person
$592
per person
Dec 26 - Dec 28
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
18.4/10 Exceptional! (1,600 reviews)
The service was a success and great breakfast. Rooms were clean and comfortable and bathroom was clean and well organized and stocked. I will have to come back to stay again for a little bit longer next time
Reviewed on Nov 18, 2025
Hilton Garden Inn St. Louis/O'Fallon MO
Price was $1,022, price is now $791 per person
$791
per person
Dec 30 - Jan 5
found 1 hour ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
17.6/10 Exceptional! (705 reviews)
No vent in the bathroom/shower area
Toilet has weak flush
Other than that a fantastic stay
Reviewed on Oct 20, 2025
The Knight Center at Washington University
Price was $625, price is now $531 per person
$531
per person
Feb 8 - Feb 10
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
18.8/10 Exceptional! (422 reviews)
One of the absolute best places I’ve ever stayed. Facilities were immaculate and I felt safe walking around. Beautiful campus!
Reviewed on Nov 16, 2025
Don't see what you're looking for?
See all available trips from Columbus to Southeast Missouri
View all tripsDiscover the most popular places to visit in Southeast Missouri
Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Lake Wappapello
4/5(18 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Rocky Falls
4.5/5(2 reviews)
Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.
Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Dec 1 to Dec 2
$102 total
Dec 1 - Dec 2
Total with taxes and fees
9.4/10 Exceptional! (1,005 reviews)
Yes
Reviewed on Nov 15, 2025
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$54 nightly
The price is $61 total per night from Nov 30 to Dec 1
$61 total
Nov 30 - Dec 1
Total with taxes and fees
8/10 Very Good! (1,004 reviews)
Yes
Reviewed on Nov 12, 2025
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $80 total per night from Nov 23 to Nov 24
$80 total
Nov 23 - Nov 24
Total with taxes and fees
7.8/10 Good! (1,003 reviews)
Room was clean but faced the road and not quiet. Also two lights were out in the room so we'll leave the light on didn't apply. Room was pitch black.
Reviewed on Nov 12, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Southeast Missouri Vacation Packages
Southeast Missouri Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
More vacations you might like
Explore a world of travel with Expedia
- Hotels near Crane Lake Recreation Area
- Des Arc Hotels
- Hotels near Walnut Hollow Lake
- Annapolis Hotels
- Cabin Rentals in Annapolis
- Cottages in Annapolis
- Hotels with Balconies in Annapolis
- 4 Star Hotels in Annapolis
- Extended Stay Hotels in Annapolis
- Motels in Annapolis
- Hotels near Silver Mine Recreation Area
- Hotels near Millstream Gardens Conservation Area
- Greenville Hotels
- Fredericktown Hotels
- Hotels near Madison County Courthouse
- Cabin Rentals in Fredericktown
- Pet-friendly Hotels in Fredericktown
- Motels in Fredericktown
- Hotels with a Pool in Fredericktown
- 3 Star Hotels in Fredericktown
- Cottages in Fredericktown
- 5 Star Hotels in Fredericktown
- B&B in Fredericktown
- Apartments in Fredericktown
- Hotels near K Bridge Recreation Area
- Hotels near Arcadia Valley Golf Club
- Arcadia Hotels
- Cabin Rentals in Arcadia
- Apartments in Arcadia
- B&B in Arcadia
- Motels in Arcadia
- Cottages in Arcadia
- Piedmont Hotels
- Vacation Homes in Piedmont
- Cabin Rentals in Piedmont
- Condo Rentals in Piedmont
- Motels in Piedmont
- 3 Star Hotels in Piedmont
- Lodges in Piedmont
- Apartments in Piedmont
- Cabin Rentals in Arcadia Valley Station
- B&B in Arcadia Valley Station
- Hotels near Arcadia Valley Station
- Ironton Hotels
- Cabin Rentals in Ironton
- B&B in Ironton
- 4 Star Hotels in Ironton
- Motels in Ironton
- Hotels with Hot Tubs in Ironton
- Historic Hotels in Ironton
- Hotels with an Outdoor Pool in Ironton
- Extended Stay Hotels in Ironton
- Vacation Homes in Ironton
- Cottages in Ironton
- 3 Star Hotels in Ironton
- Hotels near Fort Davidson State Historic Site
- Pilot Knob Hotels
- Crane Lake Recreation Area
- Walnut Hollow Lake
- Visit Annapolis
- Silver Mine Recreation Area
- Madison County Courthouse
- Fredericktown Vacations
- K Bridge Recreation Area
- Visit Fredericktown
- Arcadia Valley Golf Club
- Arcadia Vacations
- Visit Piedmont
- Visit Ironton
- Fort Davidson State Historic Site
- Taum Sauk Mountain State Park
- Car rentals near Central Fredericktown
- Car rentals near Des Arc
- Car rentals near Annapolis
- National Car Rental Rental Cars in Annapolis
- Car rentals near Greenville
- Car rentals near Cobalt
- Car rentals near Marquand
- Car rentals near Fredericktown
- Car rentals near Junction City
- Car rentals near Arcadia
- Car rentals near Piedmont
- Car rentals near Ironton
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.