Southeast Missouri Vacations from $277
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Southeast Missouri Vacation
Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.
The Latest Southeast Missouri vacation packages
Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield
per person
Sep 24 - Sep 27
found 1 day ago
Roundtrip flight included
Dallas (DAL) to St. Louis (STL)
8.2/10 Very Good! (760 reviews)
I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.
Reviewed on Jul 26, 2025
The Cheshire
per person
Sep 24 - Sep 27
found 1 day ago
Roundtrip flight included
Dallas (DAL) to St. Louis (STL)
8.6/10 Excellent! (1,000 reviews)
Bed and pillows where uncomfortable. Room and facilities were dirty. Parking was a joke due to there being 2 restaurants on the property as well so it was hard to find a spot as the hotel and restaurant shared the parking lot and garage but you had to pay to park if you stayed in the hotel.
Reviewed on Aug 3, 2025
Don't see what you're looking for?
See all available trips from Columbus to Southeast Missouri
View all tripsDiscover the most popular places to visit in Southeast Missouri
Elephant Rocks State Park
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Echo Bluff State Park
You can take time to visit Echo Bluff State Park during your travels to Salem. While you're in the area, stroll along the riverfront.
Rocky Falls
Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.
Southeast Missouri Hotel Deals
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $64 total per night from Aug 24 to Aug 25
$64 total
Aug 24 - Aug 25
Total includes taxes and fees
8/10 Very Good! (1,015 reviews)
"Clean property. Wifi could be improved."
Reviewed on Aug 11, 2025
The Riverview
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $132 total per night from Aug 17 to Aug 18
$132 total
Aug 17 - Aug 18
Total includes taxes and fees
9.2/10 Wonderful! (384 reviews)
"Good"
Reviewed on Aug 12, 2025
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $115 total per night from Aug 17 to Aug 18
$115 total
Aug 17 - Aug 18
Total includes taxes and fees
9.4/10 Exceptional! (1,005 reviews)
"I always like Drurys because you can count on the breakfast and pool and clean rooms."
Reviewed on Aug 7, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More vacations you might like
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Hotels near Crane Lake Recreation Area
- Des Arc Hotels
- Hotels near Walnut Hollow Lake
- Annapolis Hotels
- Cabin Rentals in Annapolis
- Cottages in Annapolis
- Hotels with Balconies in Annapolis
- 4 Star Hotels in Annapolis
- Extended Stay Hotels in Annapolis
- Motels in Annapolis
- Hotels near Silver Mine Recreation Area
- Hotels near Millstream Gardens Conservation Area
- Greenville Hotels
- Fredericktown Hotels
- Hotels near Madison County Courthouse
- Cabin Rentals in Fredericktown
- Pet-friendly Hotels in Fredericktown
- Motels in Fredericktown
- Hotels with a Pool in Fredericktown
- 3 Star Hotels in Fredericktown
- Cottages in Fredericktown
- 5 Star Hotels in Fredericktown
- B&B in Fredericktown
- Apartments in Fredericktown
- Hotels near K Bridge Recreation Area
- Hotels near Arcadia Valley Golf Club
- Arcadia Hotels
- Cabin Rentals in Arcadia
- Apartments in Arcadia
- B&B in Arcadia
- Motels in Arcadia
- Cottages in Arcadia
- Piedmont Hotels
- Vacation Homes in Piedmont
- Cabin Rentals in Piedmont
- Condo Rentals in Piedmont
- Motels in Piedmont
- 3 Star Hotels in Piedmont
- Lodges in Piedmont
- Apartments in Piedmont
- Cabin Rentals in Arcadia Valley Station
- B&B in Arcadia Valley Station
- Hotels near Arcadia Valley Station
- Ironton Hotels
- Cabin Rentals in Ironton
- B&B in Ironton
- 4 Star Hotels in Ironton
- Motels in Ironton
- Hotels with Hot Tubs in Ironton
- Historic Hotels in Ironton
- Hotels with an Outdoor Pool in Ironton
- Extended Stay Hotels in Ironton
- Vacation Homes in Ironton
- Cottages in Ironton
- 3 Star Hotels in Ironton
- Hotels near Fort Davidson State Historic Site
- Pilot Knob Hotels
- Crane Lake Recreation Area
- Walnut Hollow Lake
- Visit Annapolis
- Silver Mine Recreation Area
- Madison County Courthouse
- Fredericktown Vacations
- K Bridge Recreation Area
- Visit Fredericktown
- Arcadia Valley Golf Club
- Arcadia Vacations
- Visit Piedmont
- Visit Ironton
- Fort Davidson State Historic Site
- Taum Sauk Mountain State Park
- Car rentals near Central Fredericktown
- Car rentals near Des Arc
- Car rentals near Annapolis
- National Car Rental Rental Cars in Annapolis
- Car rentals near Greenville
- Car rentals near Cobalt
- Car rentals near Marquand
- Car rentals near Fredericktown
- Car rentals near Junction City
- Car rentals near Arcadia
- Car rentals near Piedmont
- Car rentals near Ironton
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.