Name: Drury Inn & Suites Sikeston, MO
Price range: $125 total

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$271

per person

Sep 17 - Sep 20

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,661 reviews)

My stay was a normal stay. Nothing special.

Reviewed on Jul 17, 2026

Remodeled and Inviting Free EV

$367

per person

Sep 3 - Sep 7

found 8 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

10/10 Exceptional! (1 review)

The property was excellent, and the home was very warm and welcoming.

Reviewed on Jun 25, 2026

The Cheshire

Save 100% on your flight

$332

per person

Sep 17 - Sep 20

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,001 reviews)

Pretty location. Direct access to the park. Cycled everywhere. Private secure car park.

Reviewed on Jul 15, 2026

Residence Inn by Marriott St Louis Downtown

Midtown

$592

per person

Sep 21 - Sep 25

found 12 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

7.8/10 Good! (1,001 reviews)

First room we were assigned smelled like thick smoke. The second room’s toilet didn’t work. The staff was not helpful and very slow to respond.

Reviewed on Jul 15, 2026

The Knight Center at Washington University

Save 100% on your flight

$295

per person

Sep 17 - Sep 20

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.4/10 Exceptional! (619 reviews)

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

100% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Jul 26 - Jul 27

Total with taxes and fees

9.6/10 Exceptional! (1,004 reviews)

"The room was smelled of BO & DIRTY FEET ! I overheard the housekeeper say they didn’t get the clean sheet delivery for the day! NEVER AGAIN!"

Reviewed on Jul 16, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$58 nightly

$63 total

Jul 26 - Jul 27

Total with taxes and fees

8/10 Very Good! (1,003 reviews)

"Breakfast"

Reviewed on Jul 16, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$109 nightly

$125 total

Jul 21 - Jul 22

Total with taxes and fees

See all 662 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.