Southeast Missouri Vacation Packages 2026 from $443

Photo by JG Morris

Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

Crowne Plaza St. Louis Airport by IHG

Save 100% on your flight

$443

per person

Nov 2 - Nov 7

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8/10 Very Good! (1,003 reviews)

Residence Inn by Marriott St. Louis West County

$487

per person

Nov 2 - Nov 7

found 15 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (265 reviews)

The hotel is the model of a well maintained and managed is.

Reviewed on Aug 30, 2026

The Wildwood Hotel

Save 100% on your flight

$463

per person

Oct 22 - Oct 25

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

9.2/10 Wonderful! (1,653 reviews)

I love the staff here!!

Reviewed on Aug 30, 2026

The Cheshire

Save 100% on your flight

$524

per person

Nov 2 - Nov 7

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,014 reviews)

A nice, interesting place, in an excellent location, right off the park. Zoo and art museum an easy stroll. My wife and I used a different St. Louis hotel for our annual trip to see my son and his family, but we tried this hotel on a whim and the Cheshire has become our new favorite.

Reviewed on Aug 31, 2026

Remodeled and Inviting Free EV

$524

per person

Oct 22 - Oct 25

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

9/10 Wonderful! (2 reviews)

It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it

Reviewed on Aug 7, 2026

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A waterfall, a river, and a red building in a forested area.

Current River State Park

9.2/10 (20 reviews)

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

96% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Sep 6 - Sep 7

Total with taxes and fees

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

Fully refundable

$74 nightly

$84 total

Sep 27 - Sep 28

Total with taxes and fees

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$57 nightly

$62 total

Sep 13 - Sep 14

Total with taxes and fees

See all 686 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.