Southeast Missouri Vacations from $277

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
Hilton Garden Inn Chesterfield
Holiday Inn Express & Suites St. Louis West - Fenton by IHG
The Cheshire
Ameristar Casino Resort and Spa
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Discover the most popular places to visit in Southeast Missouri

Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $64 total per night from Aug 24 to Aug 25
$64 total
Aug 24 - Aug 25
Total includes taxes and fees
8/10 Very Good! (1,015 reviews)
"Clean property. Wifi could be improved."

Reviewed on Aug 11, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $132 total per night from Aug 17 to Aug 18
$132 total
Aug 17 - Aug 18
Total includes taxes and fees
9.2/10 Wonderful! (384 reviews)
"Good"

Reviewed on Aug 12, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $115 total per night from Aug 17 to Aug 18
$115 total
Aug 17 - Aug 18
Total includes taxes and fees
9.4/10 Exceptional! (1,005 reviews)
"I always like Drurys because you can count on the breakfast and pool and clean rooms."

Reviewed on Aug 7, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.