Name: Drury Inn & Suites Sikeston, MO
Price range: $128 total
Rating: 9.6

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

Crowne Plaza St. Louis Airport by IHG

$376

per person

Jul 14 - Jul 18

found 16 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8/10 Very Good! (1,005 reviews)

Was in close proximity to the airport. Easy in and out for parking.

Reviewed on May 26, 2026

The Wildwood Hotel

Save 100% on your flight

$574

per person

Jul 9 - Jul 12

found 24 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,649 reviews)

I like the hotel but for the price that I paid the breakfast was terrible Frozen food and no cooked food Very disappointing for expensive hotel not to offer warm breakfast The next night we switched the hotel with holiday express because they offer good cooked breakfast

Reviewed on May 28, 2026

Hilton Garden Inn Chesterfield

$420

per person

Jul 9 - Jul 12

found 24 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.4/10 Very Good! (822 reviews)

Great hotel. Clean and the food was good.

Reviewed on May 15, 2026

Ameristar Casino Resort and Spa

$508

per person

Jul 9 - Jul 12

found 24 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,000 reviews)

I would have like to know that the indoor pool closes at 6pm. The pool was part of the reason stayed. When called previously the staff told us later hours.

Reviewed on May 28, 2026

Hermann Grain Bins BNB

$1,278

per person

Jul 25 - Jul 30

found 1 day ago

Roundtrip flight included

New York (NYC) to St. Louis (STL)

6/10 (2 reviews)

It was so comfortable and uniquely and beautifully decorated! There was so many awesome areas to explore inside and outside of the Grain Bins. Food provided for breakfast was fresh and hot. There was perfectly cooked bacon, scrambled eggs and really moist corn muffins with homemade mango preservers! We were welcomed with fresh, homemade plum bread. Instructions for everything available to utilize and operate were easy to understand. I can’t wait to go back and I will tell all my friends and family about this unique and relaxing place.

Reviewed on May 22, 2026

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Discover the most popular places to visit in Southeast Missouri

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Current River State Park

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.

What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

100% of travellers recommend

Ozark Craft Beverage - Brewery Tour

$155

per adult

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Jun 7 - Jun 8

Total with taxes and fees

9.6/10 Exceptional! (1,008 reviews)

"Hotel is beautiful, clean quiet. Breakfast and Dinner are awesome"

Reviewed on May 29, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$59 nightly

$64 total

Jun 7 - Jun 8

Total with taxes and fees

8/10 Very Good! (1,007 reviews)

"No hot water at the breakfast buffet. Food was not palatable."

Reviewed on May 30, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$111 nightly

$128 total

Jun 7 - Jun 8

Total with taxes and fees

9.6/10 Exceptional! (1,002 reviews)

"The room was clean and comfortable. The breakfast and dinner were great."

Reviewed on May 30, 2026

See all 662 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.